The Social Network, won 3 awards on the night for editing, score and Aaron Sorkin picking up the best adapted screenplay.
Natalie Portman was named best actress for her performance in Black Swan. The Fighter put up a strong fight landing two KO's with Christian Bale and Melissa Leo both winning supporting acting awards.
Inception won four awards, for cinematography, visual effects, sound mixing and sound editing, while there were two honours for Alice in Wonderland for art direction and costume design. The best make-up prize went to Rick baker and Dave Elsey for The Wolfman.
Toy Story 3 picked up Best Animated Feature and Best Song. Danish film In a Better World collected the best foreign language film prize. The best documentary feature Academy Award went to Inside Job, an examination of the recent global financial crisis.
The short film prizes went to Strangers No More for documentary, The Lost Thing for animation and God of Love for live action.
Winners in full:
Best Motion Picture of the Year
Winner: The King's Speech
Best Performance by an Actor in a Leading Role
Winner: Colin Firth for The King's Speech
Best Performance by an Actress in a Leading Role
Winner: Natalie Portman for Black Swan
Best Achievement in Directing
Winner: Tom Hooper for The King's Speech
Best Achievement in Music Written for Motion Pictures, Original Song
Winner: Toy Story 3 - Randy Newman("We Belong Together")
Best Achievement in Editing
Winner: The Social Network - Kirk Baxter, Angus Wall
Best Achievement in Visual Effects
Winner: Inception - Chris Corbould, Andrew Lockley, Pete Bebb, Paul J. Franklin
Best Documentary, Features
Winner: Inside Job - Charles Ferguson, Audrey Marrs
Best Short Film, Live Action
Winner: God of Love - Luke Matheny
Best Documentary, Short Subjects
Winner: Strangers No More - Karen Goodman, Kirk Simon
Best Achievement in Costume Design
Winner: Alice in Wonderland - Colleen Atwood
Best Achievement in Makeup
Winner: The Wolfman - Rick Baker, Dave Elsey
Best Achievement in Sound Editing
Winner: Inception - Richard King
Best Achievement in Sound Mixing
Winner: Inception - Lora Hirschberg, Gary Rizzo, Ed Novick
Best Achievement in Music Written for Motion Pictures, Original Score
Winner: The Social Network - Trent Reznor, Atticus Ross
Best Performance by an Actor in a Supporting Role
Winner: Christian Bale for The Fighter
Best Foreign Language Film of the Year
Winner: Civilization - Susanne Bier (Denmark)
Best Writing, Screenplay Written Directly for the Screen
Winner: The King's Speech - David Seidler
Best Writing, Screenplay Based on Material Previously Produced or Published
Winner: The Social Network - Aaron Sorkin
Best Animated Feature Film of the Year
Winner: Toy Story 3 - Lee Unkrich
Best Short Film, Animated
Winner: The Lost Thing - Shaun Tan, Andrew Ruhemann
Best Performance by an Actress in a Supporting Role
Winner: Melissa Leo for The Fighter
Best Achievement in Cinematography
Winner: Inception - Wally Pfister
Best Achievement in Art Direction
Winner: Alice in Wonderland - Robert Stromberg, Karen O'Hara